Tennessee Medicine E-Journal


BK virus associated nephropathy (BKVAN) is an important cause of graft dysfunction with a high rate of graft loss. Current literature describes the pathophysiology of Polyoma Virus Associated Nephropathy (PVAN) induced by BKV but it lacks detailed definition of allograft nephropathy induced by JC virus (JCV). BKVAN is typically associated with BK Viremia, and the latter is the most commonly used screening measure for BKVAN in most transplant centers [1]. We are reporting a case of JCV associated nephropathy in renal allograft recipient who did not have JC viremia during the entire course of his disease and did not respond to reduction of immunosuppression and antiviral therapy.